MRGX1 rabbit pAb - 100 μL

Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G (alpha)q proteins are involved in the calcium-signaling pathway. similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.