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LARGE antibody

https://antibody.odoo.com/web/image/product.template/94457/image_1920?unique=8395eee

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Bifunctional glycosyltransferase with both xylosyltransferase and beta-13-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide(N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan(DAG1)(PubMed : 22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracell µLar proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-14-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-13-GlcA-beta-1-] to produce a heteropolysaccharide(PubMed : 25279699).
Immunogen : like-glycosyltransferase
Aliases : KIAA0609, LARGE1
Observed MW : 65-70 kDa
Uniprot ID : O95461
Reactivity : Human, Mouse
Application : ELISA, WB
Recommended dilution : WB : 1 : 500-1 : 2000
Gene ID : 9215
Research Area : Metabolism

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